U.S., Jan. 16 -- ClinicalTrials.gov registry received information related to the study (NCT07343154) titled 'Multimodal Brain Function in Migraine Patients With Patent Foramen Ovale' on Jan. 06.
Brief Summary: This investigator-initiated, single-center prospective study is designed to clarify how patent foramen ovale (PFO) relates to brain function abnormalities in patients with drug-refractory migraine with aura (MA), and whether percutaneous PFO closure is associated with measurable, longitudinal improvements in neurophysiological and neuroimaging markers as well as clinical symptoms.
The study addresses two core questions: (1) Do MA patients with clinically significant right-to-left shunt due to PFO demonstrate distinct resting-state b...