Clinical Trial: Metformin as Adjunct Therapy in Depression-Obesity Comorbidity: Clinical and Genetic Evaluation

U.S., June 18 -- ClinicalTrials.gov registry received information related to the study (NCT07654179) titled 'Metformin as Adjunct Therapy in Depression-Obesity Comorbidity: Clinical and Genetic Evaluation' on June 13.

Brief Summary: The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy. NEGR1/RPL31P12 gene polymorphisms may influence the comparative efficacy of antidepressant monotherapy versus combination therapy (antidepressant + metformin) in Pakistani patients. Patients with certain variants may respond better or worse to antidepressants and may have different weight outco...