Clinical Trial: Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND)

U.S., Oct. 10 -- ClinicalTrials.gov registry received information related to the study (NCT07867210) titled 'Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND)' on Oct. 05.

Brief Summary: The goal of this pilot clinical trial is to learn whether memantine can be given safely and successfully to adults in hospital with a mild or moderate traumatic brain injury (TBI). Memantine is approved to treat Alzheimer's disease, but it is not approved to treat TBI. The study will also test whether brain scans and other assessments are suitable for a larger trial.

TBI can damage the blood-brain barrier. This protective lining controls what can pass from the bloodstream into the brain. Researchers can me...