Clinical Trial: Intrathecal Dexmedetomidine 5 mcg Versus 10 mcg With Bupivacaine for Infra-umbilical Surgery

U.S., Nov. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07929818) titled 'Intrathecal Dexmedetomidine 5 mcg Versus 10 mcg With Bupivacaine for Infra-umbilical Surgery' on Oct. 31.

Brief Summary: This randomized controlled trial compares two isovolumetric intrathecal doses of dexmedetomidine (5 micrograms and 10 micrograms) added to 12.5 mg hyperbaric bupivacaine for spinal anaesthesia in adults undergoing elective infra-umbilical surgery. A total of 544 patients are randomly allocated into two groups of 272 each. The incidence of intraoperative hypotension is the primary outcome. Intraoperative bradycardia, number of hypotensive and bradycardic episodes, rescue drug use and time to two-segment regression ...