Clinical Trial: Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients

U.S., Nov. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07914803) titled 'Intranasal Dexmedetomidine-esketamine Combination and Postoperative Cognitive Recovery in Older Patients' on Oct. 29.

Brief Summary: Postoperative neurocognitive disorders, including postoperative delirium (POD) and delayed neurocognitive recovery (dNCR), are common in older patients undergoing surgery and are associated with worse outcomes. Intranasal dexmedetomidine, esketamine, and their combination have been used in clinical practice to improve sleep quality and analgesia. A preliminary study suggested lower rates of emergence delirium and POD/dNCR in older patients receiving perioperative intranasal dexmedetomidine-esketamine. T...