U.S., July 28 -- ClinicalTrials.gov registry received information related to the study (NCT07728032) titled 'Impact Of A Phe-Restricted Diet On Gut Health In Children With PKU' on July 21.
Brief Summary: Phenylketonuria (PKU) is an inherited disorder of phenylalanine (Phe) metabolism. The mainstay of treatment is a Phe-restricted diet, which aims to maintain blood Phe concentrations within the recommended range and prevent neurological complications. Some individuals with PKU respond to pharmacological treatments, including sapropterin, a synthetic form of tetrahydrobiopterin (BH4), or sepiapterin. These treatments may increase Phe tolerance and allow a less restrictive diet.
Diet is an important determinant of gut microbiota composition ...