U.S., Feb. 18 -- ClinicalTrials.gov registry received information related to the study (NCT07411911) titled 'Hydrogen In Neonatal Encephalopathy (HIE) Trial' on Nov. 25, 2025.
Brief Summary: Despite advances in neonatal care, moderate-to-severe acute perinatal HIE in late preterm and term infants remains a cause of mortality, neurological injury, and long-term neurodevelopmental disability. The current standard of care includes therapeutic hypothermia for 72 hours, but 40-50% of infants will die or suffer significant neurodevelopmental impairment. It has been shown that administration of hydrogen gas (H2) significantly diminishes ischemic injury in swine, and that H2 administration at the dose and duration proposed herein is well-tolerated...