Clinical Trial: First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers

U.S., Oct. 8 -- ClinicalTrials.gov registry received information related to the study (NCT07864142) titled 'First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers' on Oct. 01.

Brief Summary: Open neural tube defects are congenital malformations associated with significant morbidity. Early detection during the first trimester remains a key challenge.

This retrospective monocentric study aims to evaluate the diagnostic performance of fetal biometrics (biparietal diameter and abdominal transverse diameter ratios) and maternal serum markers (beta-hCG and PAPP-A) for early screening of open neural tube defects. The study will assess the predictive value of these parameters individually and in combinat...