Clinical Trial: First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE-4D Imaging in Healthy Volunteers

U.S., Oct. 3 -- ClinicalTrials.gov registry received information related to the study (NCT07853781) titled 'First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE-4D Imaging in Healthy Volunteers' on Oct. 01.

Brief Summary: Background:

PDE-4D is a protein found in the brain. It helps control chemical signals that affect mood, memory, and thinking. Problems with PDE-4D may play a role in depression and Alzheimer disease. Being able to measure PDE-4D levels in the body would help doctors identify and manage these diseases. Researchers want to find out if a new tracer (a radioactive substance injected during imaging scans) can help them see PDE-4D in people more effectively.

Objective:

To test a new tracer ([11C]JMJ-129-d2) during imaging sc...