U.S., March 28 -- ClinicalTrials.gov registry received information related to the study (NCT07494032) titled 'Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty' on March 20.
Brief Summary: This study is a prospective double-blind randomized controlled trial to evaluate the effect of extended oral TXA after primary total TKA on short-term and mid-term postoperative outcomes, including function, pain, and postoperative complications over a 24-month period, with evaluations at 6 weeks, 3 months, 12 months, and 24 months. Each group of 175 patients will receive either extended oral TXA 1.95g daily or placebo for 7 days postoperatively. Function will be assessed by Knee Injury and Osteoarthritis Outcome Score, Joint Replacemen...