U.S., Nov. 6 -- ClinicalTrials.gov registry received information related to the study (NCT07918417) titled 'Exercise in Alzheimer's Disease: Functional Biomarkers' on Oct. 26.
Brief Summary: Alzheimer's disease (AD) is the leading cause of dementia worldwide and involves systemic alterations beyond the brain, such as loss of muscle strength, chronic low-grade inflammation, and gut microbiome dysbiosis. Physical exercise is a promising non-pharmacological therapy, and velocity-based resistance training has proven safe and effective in older adults. However, the effects of performing resistance exercises at high versus moderate velocity in people with AD remain unknown, and human evidence on how exercise modulates the gut microbiome in AD is...