U.S., Feb. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07424378) titled 'Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO)' on Jan. 28.
Brief Summary: Severe frostbite injury can result in significant lifelong disability and amputation. Various medicines, including intravenous vasodilators (prostaglandins/iloprost, pentoxifylline, buflomedil) along with thrombolytics (alteplase), have been described to counter tissue ischemia after rewarming, with poor quality of evidence. An in-class prostacyclin, epoprostenol, has similar pharmacodynamic properties to iloprost including vasodilation and platelet inhibition and has been used in peripheral tissue ischemia such as Raynaud's and sc...