Clinical Trial: Emulation of the MAVERICC Trial Using Specialty Oncology Electronic Health Records Databases

U.S., Oct. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07861386) titled 'Emulation of the MAVERICC Trial Using Specialty Oncology Electronic Health Records Databases' on Sept. 29.

Brief Summary: This trial emulation study aims to emulate the MAVERICC trial (NCT01374425) using real-world specialty oncology electronic health record data and to investigate the concordance between the trial's original and emulated treatment effect estimates on overall survival (OS). MAVERICC was a Phase II, open-label, randomized study assessing the efficacy and safety of modified leucovorin/5-fluorouracil/ oxaliplatin plus bevacizumab (mFOLFOX6-BV) with leucovorin/5-fluorouracil/irinotecan plus bevacizumab (FOLFIRI-BV) in pa...