U.S., Sept. 13 -- ClinicalTrials.gov registry received information related to the study (NCT07170176) titled 'Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine' on Sept. 07.
Brief Summary: Patent Foramen Ovale (PFO) is a common congenital heart defect. Recent studies have suggested a potential association between PFO and migraines, particularly migraine with aura. It is hypothesized that PFO may allow microemboli or vasoactive substances from venous blood to bypass pulmonary metabolism and enter the arterial system directly, potentially triggering migraines. Although PFO closure has been shown to reduce the frequency and severity of migraine attacks, its long-term efficacy and underlying mechanis...