U.S., June 25 -- ClinicalTrials.gov registry received information related to the study (NCT07664319) titled 'Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults' on June 17.
Brief Summary: This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults undergoing tympanoplasty for chronic otitis media with tympanic membrane perforation. Forty-eight patients were allocated by systematic alternation to a PRP group (PRP-impregnated Spongostan placed in the middle ear and lateral to the graft) or a control group (dry Spongostan). The primary outcome...