Clinical Trial: Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.

U.S., Nov. 7 -- ClinicalTrials.gov registry received information related to the study (NCT07923669) titled 'Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.' on Nov. 02.

Brief Summary: This randomized clinical trial aims to compare the effects of conventional, cryotherapeutic, and nanotherapeutic sodium hypochlorite solutions used as final root canal irrigants on postoperative pain and substance P levels.

The study will include 45 patients aged 18-50 years with symptomatic irreversible pulpitis and symptomatic apical periodontitis affecting single-rooted mandibular premolars.

Participants will be randomly assigned to three equal groups (15 patients per group). The first group will recei...