Clinical Trial: DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy

U.S., Aug. 11 -- ClinicalTrials.gov registry received information related to the study (NCT07754578) titled 'DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy' on Aug. 04.

Brief Summary: This randomized clinical trial evaluates the effectiveness of augmented-dose combination nicotine replacement therapy (NRT) versus standard-dose NRT and no-NRT control for cessation of dual combustible cigarette (CC) and electronic cigarette (EC) use. Adults who currently engage in dual use and are motivated to quit both products will be assigned to one of three 12-week interventions: (1) no pharmacotherapy (behavioral support only), (2) standard-dose NRT (21 mg nicotine patch + 4 mg lozenges, 5-20/day), or (3) augmented-dose NRT (...