Clinical Trial: Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients

U.S., Sept. 16 -- ClinicalTrials.gov registry received information related to the study (NCT07819864) titled 'Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients' on Sept. 09.

Brief Summary: Rationale:

Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning. Recent ex vivo work suggests that a subset of mechanically ventilated ICU patients may exhibit diaphragm hibernation, an energy conserving myosin state that reduces force generation and may lead to a reversible increase in diaphragm strength over time. However, it is unknown whether diaphragm hibernation can be demonstrated in vivo during IMV and which clinical and biological factor...