U.S., Aug. 21 -- ClinicalTrials.gov registry received information related to the study (NCT07776444) titled 'Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography' on Sept. 22, 2025.
Brief Summary: The purpose of the study protocol is to identify imaging biomarkers for brain tissue under high metabolic stress at risk for permanent injury. We will measure oxygen extraction fraction (OEF) and cerebrovascular reactivity (CVR) in participants with and without perturbations in cerebral oxygen delivery over time to determine each parameter's role in clinical and radiologic neurologic outcomes. Measuring OEF can be done with specialized MRI sequences. Measuring CVR requires a vasoactive response, such as carbon diox...