Clinical Trial: Cardiac Output and Fatigue in Friedreich's Ataxia

U.S., March 3 -- ClinicalTrials.gov registry received information related to the study (NCT07444333) titled 'Cardiac Output and Fatigue in Friedreich's Ataxia' on Nov. 17, 2025.

Brief Summary: AIM 1: Acceptability and Feasibility of Home Aerobic Exercise. Individuals with other types of ataxia have been able to train at the above levels safely. We hypothesize that there will be no serious adverse events related to aerobic training, and there will be an acceptable number of minor adverse events. We further hypothesize that drop-out from the trial will be less than 25%.

AIM 2: Impact of Omaveloxolone on VO2max. Omaveloxolone works by activating and preventing the degradation of Nuclear factor-like 2 (Nrf2), which helps prevent oxidative dam...