Clinical Trial: Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age

U.S., July 7 -- ClinicalTrials.gov registry received information related to the study (NCT07685431) titled 'Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age' on June 29.

Brief Summary: Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respiratory chain activity and ATP production. This prospective study will enroll 60 infertile women aged 35-45 years undergoing in vitr...