Clinical Trial: All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular Brucellosis

U.S., Oct. 22 -- ClinicalTrials.gov registry received information related to the study (NCT07887152) titled 'All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular Brucellosis' on Oct. 15.

Brief Summary: Brucellosis is a globally distributed zoonosis with persistent clinical management challenges. The World Health Organization (WHO)-recommended doxycycline-rifampin (DOX-RIF) dual regimen may drive rifampin-associated antimicrobial resistance in brucellosis-endemic regions. Patients with osteoarticular brucellosis, the most common focal complication of brucellosis, often require long-term intravenous ceftriaxone triple therapy. This parenteral regimen leads to poor treatment adherence, frequent hosp...