U.S., March 21 -- ClinicalTrials.gov registry received information related to the study (NCT07485803) titled 'A RCT Using Methadone in the Management of Post-Operative Pain in Total Knee Replacement' on March 17.
Brief Summary: The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.
Study Start Date: June, 2026
Study Type: INTERVENTIONAL
Condition:
Total Knee Arthroplasty
Intervention:
DRUG: Methadone
Subjects randomized to receive methadone will be given one dose of methadone 0.15mg/kg intravenously dosed based on ideal body weight administered by t...