Singapore Clinical Trial: Role of glucagon-like peptide 1 receptor Agonist (GLP1 RA) Dulaglutide on cerebral hemodynamics In patients with severe and symptomAtic steNosis of inTracranial internal carotid artery or middle cerebral artery with impaired cerebral vasodilatory reserve- an open-label randomised clinical trial (RADIANT)

Singapore, April 25 -- The Health Sciences Authority received information related to the study titled 'Role of glucagon-like peptide 1 receptor Agonist (GLP1 RA) Dulaglutide on cerebral hemodynamics I... Read More

Singapore Clinical Trial: A randomized, placebo-controlled, participant- and investigator-blinded study to evaluate the efficacy in reducing atrial fibrillation burden (AFB) as well as the safety, tolerability, and pharmacokinetics of oral PKN605 in participants with atrial fibrillation

Singapore, April 25 -- The Health Sciences Authority received information related to the study titled 'A randomized, placebo-controlled, participant- and investigator-blinded study to evaluate the eff... Read More

Singapore Clinical Trial: A Phase 2/3 Randomized Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab Adizutecan in Combination with Osimertinib as First-Line Treatment in Patients with Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Singapore, April 25 -- The Health Sciences Authority received information related to the study titled 'A Phase 2/3 Randomized Study to Evaluate the Safety, Efficacy, and Optimal Dose of Telisotuzumab ... Read More

Singapore Clinical Trial: A Study to Evaluate the Effect of Fasting Duration and Temporary Withholding of Tirzepatide on Retained Gastric Contents Using Gastric Ultrasound in Participants with Type 2 Diabetes Mellitus and Participants with Overweight or Obesity without Type 2 Diabetes Mellitus.

Singapore, April 25 -- The Health Sciences Authority received information related to the study titled 'A Study to Evaluate the Effect of Fasting Duration and Temporary Withholding of Tirzepatide on Re... Read More

Singapore Clinical Trial: A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents in Combination With Pembrolizumab (MK-3475) With or Without Chemotherapy in Participants With 1L Locally Advanced Unresectable/Metastatic Esophageal Cancer: KEYMAKER-U06 Substudy 06E

Singapore, April 25 -- The Health Sciences Authority received information related to the study titled 'A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents in Combination W... Read More

Clinical Trial: A Phase I Study of HRS-5765 in Healthy Participants

U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07551167) titled 'A Phase I Study of HRS-5765 in Healthy Participants' on April 20. Brief Summary: The purp... Read More

Clinical Trial: Effect Of Game-Based Breathing Exercise On Pain, Fear, And Anxiety In Children During Venipuncture

U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07550062) titled 'Effect Of Game-Based Breathing Exercise On Pain, Fear, And Anxiety In Children During Veni... Read More

Clinical Trial: Model-Informed Precision Dosing of Tacrolimus in Pediatric Kidney Transplantation

U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07549230) titled 'Model-Informed Precision Dosing of Tacrolimus in Pediatric Kidney Transplantation' on Apri... Read More

Clinical Trial: CBD Wall-Thickness Adjusted ICG Microdosing for Fluorescence Cholangiography in Moderate-to-Severe Acute Cholecystitis: A Single-Center Prospective Study

U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07551388) titled 'CBD Wall-Thickness Adjusted ICG Microdosing for Fluorescence Cholangiography in Moderate-t... Read More

Clinical Trial: Ultrasound-guided Versus Landmark-based Spinal Anesthesia in Obese Parturients Undergoing Cesarean Section

U.S., April 25 -- ClinicalTrials.gov registry received information related to the study (NCT07549776) titled 'Ultrasound-guided Versus Landmark-based Spinal Anesthesia in Obese Parturients Undergoing ... Read More

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