New Delhi, Sept. 17 -- Wall Street's key stock indices were mixed on Wednesday ahead of a widely anticipated interest-rate cut from the Federal Reserve later in the day.

At 10:08 AM ET, the Dow Jones Industrial Average rose 249.20 points, or 0.54%, to 46,007.10, the S&P 500 lost 4.69 points, or 0.07%, to 6,602.07, and the Nasdaq Composite fell 73.47 points, or 0.33%, to 22,259.64.

At the opening bell, the Dow Jones Industrial Average rose 20.5 points, or 0.04%, to 45,778.4. The S&P 500 fell 1.9 points, or 0.03%, to 6,604.87, while the Nasdaq Composite dropped 0.9 points, or flat, at 22,333.016.

The US central bank is overwhelmingly expected to slash interest rates by 25 basis points.

The Fed meeting comes as US President Donald Trump ...