New Delhi, Oct. 27 -- The New York Giants suffered a heartbreaking setback on Sunday as rookie running back Cam Skattebo was carted off the field with a serious lower right leg injury during their matchup against the Philadelphia Eagles.

Midway through the second quarter, Cam Skattebo's day took a devastating turn. The fourth-round draft pick was reaching for a pass over the middle when his right ankle became trapped under an Eagles defender. His foot twisted sharply to the right in a sight that left players and fans stunned.

Both teams reacted instantly to the severity of the injury. One Eagles player sprinted away from the scene and off the field, while several Giants teammates turned their backs, unable to watch. Rookie quarterback J...