New Delhi, Oct. 25 -- The Philadelphia Eagles face a major setback as they prepare to clash with NFC East rivals, the New York Giants, in NFL Week 8. Star wide receiver AJ Brown has been officially ruled out because of a nagging hamstring injury, stripping the offense of its top playmaker ahead of this crucial divisional showdown.

AJ Brown, the Eagles' premier pass-catcher, sat out every practice session this week, signalling trouble for his availability. Head coach Nick Sirianni confirmed the decision on Friday, listing Brown among four players definitively out for Sunday's game at Lincoln Financial Field.

Joining Brown on the sidelines are cornerback Adoree' Jackson (concussion), offensive lineman Cam Jurgens (knee), and pass rusher A...