MUMBAI, India, July 31 -- Intellectual Property India has published a patent application (202411100971 A) filed by National Institute Of Pharmaceutical Education And on December 19, 2024, for Green And Scalable Process For Synthesizing Sorafenib And Regorafenib.
Inventors include Joydev Kumar Laha; Anjali Gupta; and Shubham B Chaudhari.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: The present disclosure relates to a green and transition metal-free process for the preparation of Sorafenib and Regorafenib, two clinically significant antineoplastic agents. The method involves the oxidative carbamoylation of 4-chloro-3-(trifluoromethyl)aniline with semicarbazide to form 1-(4-chloro-3- (tri...