MUMBAI, India, Oct. 12 -- Intellectual Property India has published a patent application (202617085819 A) filed by Sanofi C on July 13, 2026, for Effectorless Igg1 Fc Variants.
Inventors include Lange, Christian; Langer, Thomas; and Rao, Ercole.
The application for the patent was published on October 09, 2026, under issue no. 41/2026.
Abstract: The present invention relates to IgG1 Fc variants which do not elicit antibody effector functions, such as CDC, ADCP and ADCC. In particular, the present invention relates to IgG1 Fc variant polypeptides which comprise the mutations L234A, L235A, A327G, P329A, A330S, and P331S, according to EU numbering, molecules comprising such IgG1 Fc variant polypeptides and uses of such molecules to reduce an...