India, Aug. 28 -- University of Toronto scientists have found a novel RNA therapy approach that acts like a biological bypass, teaching cells to ignore faulty genetic "stop instructions" and produce missing, vital proteins naturally. The RNA mechanism, the scientists said, could bypass genetic stop signals across different inherited conditions, offering significant implications.

Suppressor transfer RNAs (sup- tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTC). Their clinical translation is limited by suboptimal activity and inefficient in vivo delivery, the scientists said in a paper. A codon is a sequence of three DNA or RNA nucleotides that codes for a specific amino acid...