India, Sept. 5 -- The San Francisco 49ers will kick off their 2025 NFL season on the road against the division-rival Seattle Seahawks in a Week 1 showdown at Lumen Field on Sunday.

A key storyline ahead of Sunday's game is the health status of star running back Christian McCaffrey, who appeared on the injury report for the first time this week. According to ESPN's NFL Insider Adam Schefter, McCaffrey was limited in practice on Thursday due to a calf issue. His availability for the season opener remains uncertain.

If McCaffrey is unable to play, Brian Robinson Jr. is expected to take over as the starting running back. Robinson, traded from the Washington Commanders during the offseason, is currently listed as McCaffrey's primary backup. ...