Geneva, Jan. 12 -- International Clinical Trials Registry received information related to the study (ChiCTR2500115604) titled 'Management of Orthoplastic combined ERAS in severe open fractureand the underlying molecular mechanism of infection' on Dec. 29, 2025.

Study Type: Interventional study

Study Design: Parallel

Primary Sponsor: Zhuzhou central hospital

Condition: Severe open fracture

Intervention: control group:The control group underwent routine one-stage treatment, which included thorough debridement, fixation of fractures with external fixation braces, and coverage of the wound with VSD. In the second stage, skin flaps were used to cover the wound. In the third stage, after the wound had healed, the external fixation brace...