International Clinical Trial: Effects of low-dose dexmedetomidine combined with esketamine infusion on sleep in non-mechanical ventilation patients with sepsis in ICU: a multicenter, randomized, double-blind, placebo-controlled study

Geneva, Jan. 12 -- International Clinical Trials Registry received information related to the study (ChiCTR2500115440) titled 'Effects of low-dose dexmedetomidine combined with esketamine infusion on sleep in non-mechanical ventilation patients with sepsis in ICU: a multicenter, randomized, double-blind, placebo-controlled study' on Dec. 26, 2025.

Study Type: Interventional study

Study Design: Parallel

Primary Sponsor: Peking University First Hospital

Condition: Sepsis

Intervention: Test group:The initial infusion rate is [0.025xkg]·ml/h (equivalent to 0.05 g/kg/h for dexmedetomidine and 0.025 mg/kg/h for esmolol). Depending on the patients condition, the infusion rate can be increased by [0.025xkg]·ml/h (equivalent to 0...