U.S., June 25 -- ClinicalTrials.gov registry received information related to the study (NCT07666568) titled 'Younger vs. Older Donors in Allo-HSCT: TTE' on June 15.
Brief Summary: Hematopoietic stem cell transplantation is an important therapeutic approach for hematologic malignancies, and the impact of donor age on transplant outcomes remains an active area of investigation. Older donors may be associated with impaired stem cell fitness, delayed immune reconstitution, and reduced T-cell function. However, randomized controlled trials directly comparing transplant outcomes by donor age are difficult to conduct because of ethical constraints, and previous retrospective studies have yielded inconsistent findings due to confounding bias and l...