U.S., Jan. 6 -- ClinicalTrials.gov registry received information related to the study (NCT07317921) titled 'Validating IAAO for Muscle Outcomes' on Dec. 18, 2025.
Brief Summary: Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies. Alternative non-invasive methodologies have been developed (namely the indicator amino acid oxidation (IAAO) technique) to estimate the impact of protein ingestion on whole-body protein synthesis as a proxy for determining dietary protein requirements. Given that the IAAO technique is based on principles of protein metabolism which occur in the liver, it i...