Clinical Trial: Utility of Whole Genome Sequencing in Fetuses With Abnormal Ultrasound Findings

U.S., May 27 -- ClinicalTrials.gov registry received information related to the study (NCT07606989) titled 'Utility of Whole Genome Sequencing in Fetuses With Abnormal Ultrasound Findings' on April 09.

Brief Summary: The goal of this observational study is to learn if whole-genome sequencing (WGS) can help find the genetic cause in fetuses with structural abnormalities that remain unexplained after standard genetic testing (such as karyotyping, chromosomal microarray, or whole-exome sequencing). It will also learn how WGS results may affect pregnancy management and family decision-making.

The main questions it aims to answer are:

How often does WGS identify a genetic cause in these fetuses? Does WGS find more genetic causes compared to s...