Clinical Trial: Upadacitinib in Isolated Small Bowel Versus Non-Small Bowel Crohn's Disease

U.S., May 20 -- ClinicalTrials.gov registry received information related to the study (NCT07597577) titled 'Upadacitinib in Isolated Small Bowel Versus Non-Small Bowel Crohn's Disease' on May 09.

Brief Summary: Background & Aims: Isolated small bowel Crohn's disease (CD) is defined by involvement of the ileum, jejunum, or extensive small intestinal segments in the absence of colonic disease. This phenotype presents a therapeutic challenge, as biologic agents demonstrate reduced efficacy in this subgroup. Data on the use of upadacitinib specifically for isolated small bowel CD remain limited. This study aimed to evaluate the efficacy of upadacitinib in patients with this phenotype using the International Bowel Ultrasound Segment Activity Sc...