U.S., Feb. 19 -- ClinicalTrials.gov registry received information related to the study (NCT07418658) titled 'Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function' on Jan. 26.
Brief Summary: The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs). The objective of the study is to characterise disease-driven gastrointestinal (GI) changes that occur prior to initiation of treatment.
The main questions this study aims to answer are:
1. Are there changes in duodenal permeability in people with untreated PD?
2. Are there changes in the gut microbiome in people with untreated PD?
3. Are these gut cha...