U.S., March 25 -- ClinicalTrials.gov registry received information related to the study (NCT07490574) titled 'Trial of Underwater Versus Gas-Insufflation Colorectal Endoscopic Submucosal DisseEtion' on March 18.
Brief Summary: Colorectal endoscopic submucosal dissection (ESD) enables en bloc resection of large superficial colorectal neoplasia but remains technically demanding and may be limited by suboptimal visualization, intraprocedural bleeding, smoke accumulation, and prolonged procedural time. Underwater ESD (UESD), performed under saline immersion rather than gas insufflation, has been proposed as a strategy to improve the operative field and facilitate submucosal dissection.
This prospective, multicenter, open-label, randomized con...