U.S., Nov. 5 -- ClinicalTrials.gov registry received information related to the study (NCT07916831) titled 'Tissue Penetration of Paracetamol in Pediatric Intensive Care Patients' on Oct. 29.
Brief Summary: TIPPIC was a single-centre, prospective, observational pharmacokinetic study in critically ill children aged 1 month to 15 years who were admitted to the paediatric intensive care unit (PICU) of Ghent University Hospital with an external ventricular drain (EVD) in place and who received intravenous (IV) paracetamol as part of routine care.
Paracetamol is thought to act in the central nervous system and must cross the blood-brain barrier to reach its target. Severe intracranial pathology (for example traumatic brain injury or brain tumo...