U.S., Sept. 17 -- ClinicalTrials.gov registry received information related to the study (NCT07822243) titled 'Tissue Penetration of Antibiotics in CriTically Ill Children' on Sept. 10.
Brief Summary: This clinical study evaluates the extent to which three commonly administered beta-lactam antibiotics (piperacillin-tazobactam, meropenem, and amoxicillin-clavulanic acid) penetrate tissue in critically ill pediatric patients.
The primary objectives of this study are to:
* Determine whether tissue penetration of beta-lactam antibiotics is impaired in critically ill pediatric patients during initial dosing and steady-state conditions.
* Evaluate whether antibiotic concentrations within interstitial tissue fluid achieve defined pharmacokineti...