U.S., Aug. 12 -- ClinicalTrials.gov registry received information related to the study (NCT07113730) titled 'The Kinetics Profiling of Immune Reconstitution and Clinical Outcomes' on July 27.
Brief Summary: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy with poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative treatment. Immune reconstitution (IR) is critical for improving HSCT efficacy and quality of life among survivors, yet its dynamic impact on survival and complications like chronic graft-versus-host disease (cGVHD) in CMML is poorly defined. This study aimed to investigate the dynamics of IR following HSCT in patients with CMML and evaluate its im...