U.S., May 9 -- ClinicalTrials.gov registry received information related to the study (NCT07575737) titled 'The Impact of Preoperative Statin Therapy and and Its Intensity on Postoperative and Mortality and Morbidity' on May 04.
Brief Summary: Statins are among the most widely prescribed drugs worldwide, and their benefits in cardiovascular risk reduction are well established. Beyond lipid lowering, statins exert pleiotropic effects - including anti-inflammatory, antioxidant, and endothelial-stabilizing properties - that have generated longstanding interest in their potential to mitigate perioperative complications.
Major surgery provokes a systemic inflammatory response, endothelial activation, and hemodynamic stress that may precipitate ...