U.S., April 8 -- ClinicalTrials.gov registry received information related to the study (NCT07514364) titled 'The Effect of Rifabutin in Mycobacterium Abscessus With Inducible Clarithromycin Resistance' on March 20.
Brief Summary: Background: Mycobacterium abscessus, one of the most common species of nontuberculous mycobacterium (NTM), poses a significant clinical challenge due to its natural resistance to antibiotics and high treatment failure rates, particularly in lung diseases. Among its subspecies, M. abscessus subspecies abscessus is especially prone to developing inducible resistance to Clarithromycin. This resistance mechanism is primarily due to the activation of the erm(41) gene,which inhibits Clarithromycin from effectively bindi...