Clinical Trial: The Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block.

U.S., May 27 -- ClinicalTrials.gov registry received information related to the study (NCT07606911) titled 'The Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block.' on May 19.

Brief Summary: This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity surgery. The primary aim is to assess whether the combination reduces the incidence or severity of rebound pain (i.e., more effectively covers the postoperative inflammatory peak on days 2-3 and provides a smoother regression curve of sensory blockade). Secondary aims include evaluation of upper limb func...