Clinical Trial: Testing APPA-1 in Healthy Subjects and Osteoarthritis Patients

U.S., Feb. 25 -- ClinicalTrials.gov registry received information related to the study (NCT07429565) titled 'Testing APPA-1 in Healthy Subjects and Osteoarthritis Patients' on Jan. 22, 2018.

Brief Summary: To determine the safety and tolerability of ascending single and multiple oral doses of APPA-1 in healthy subjects and osteoarthritis patients.

To determine the single and multiple oral dose pharmacokinetics of APPA-1 constituents (paeonol/apocynin) in healthy subjects and osteoarthritis patients.

To determine the effect of food on the single oral dose pharmacokinetics of APPA-1 constituents (paeonol/apocynin) in healthy subjects.

To determine the effect of gender on the single oral dose pharmacokinetics of APPA-1 constituents (paeono...