U.S., April 23 -- ClinicalTrials.gov registry received information related to the study (NCT07544966) titled 'Teen Vulnerability to Irritability: Brain and Estrogen Changes' on Feb. 02.
Brief Summary: Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly during the abrupt withdrawal of estradiol (E2) and progesterone (P4) prior to menses onset. Irrefutable evidence links stress with affective symptoms, potentially mediated by E2-related modifications of frontolimbic connectivity and prefrontal gamma-aminobutyric acid (GABA) inhibitory signaling. The primary objective...