Clinical Trial: Targeting the Hepatic BMP-SMAD Pathway in Leptin Receptor Deficiency (LEPRD)

U.S., Sept. 23 -- ClinicalTrials.gov registry received information related to the study (NCT07833592) titled 'Targeting the Hepatic BMP-SMAD Pathway in Leptin Receptor Deficiency (LEPRD)' on Sept. 07.

Brief Summary: The goal of this observational study is to learn more about the role of TMPRSS6 in patients with leptin receptor deficiency (LEPRD) or genetic lipodystrophy associated with leptin deficiency. LEPRD is a rare genetic condition that causes severe obesity and excessive hunger, while genetic lipodystrophy is characterized by a loss of body fat and can be associated with severe metabolic problems.

The main questions it aims to answer are:

Is TMPRSS6 associated with metabolic and liver health in patients with LEPRD or genetic lipod...