U.S., April 2 -- ClinicalTrials.gov registry received information related to the study (NCT07505979) titled 'SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases' on March 24.
Brief Summary: The goal of this phase II randomized trial is to determine if Stereotactic Radiosurgery (SRS) or Cognitive Sparing WBRT (CS-WBRT) better preserves neurocognitive function than standard Hippocampal Avoidance WBRT (HA-WBRT) in patients with multiple brain metastases ( $\ge6$ lesions).
The main questions it aims to answer are:
* Which treatment best preserves cognitive function (memory and executive tasks) at 6 months post-intervention?
* Can sparing the left hippocampus and corpus callosum (CS-WBRT) or using focal SRS reduce...