U.S., April 15 -- ClinicalTrials.gov registry received information related to the study (NCT07528872) titled 'Serum COMP and MMP-3 in Knee Osteoarthritis' on April 07.
Brief Summary: Knee osteoarthritis is a common degenerative joint disease characterized by pain, stiffness, and functional limitation, significantly affecting quality of life. In addition to mechanical factors, cartilage degradation and extracellular matrix remodeling play a key role in disease progression. Therefore, identifying reliable biomarkers reflecting disease severity has become an important research focus.
Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage associated with cartilage turnover, while matrix metalloproteinase-3 (MMP-3) i...